Genome Editing and Disease Modeling of Bone Monogenic Disorders - a webinar by Dr. Ing. Jeroen van de Peppel, 20th June 4pm

Craniosynostosis is a congenital condition involving the premature fusion of one or more cranial sutures during a newborn's development, caused by mutations in multiple genes. A commonly affected gene is FGFR2, which has various mutations linked to syndromic forms of craniosynostosis such as Crouzon, Apert, and Pfeiffer Syndromes. This webinar will cover the creation of human adult and pluripotent stem cells derived from craniosynostosis patients, and the application of genome editing techniques to develop and study disease models of monogenic bone disorders.

Key takeaways: 

• Explore the processes involved in creating human adult and pluripotent stem cells from patients with craniosynostosis.

• Discover the techniques and applications of genome editing used to generate and study disease models of monogenic bone disorders.

• Understand how disease models are developed and utilized to study the pathology and potential treatments for craniosynostosis and other monogenic bone disorders.

Format: Webinar of 30 minutes of research topics of Genome editing and in vitro disease modelling by Dr. Jeroen van de Peppel followed by a discussion.

Joining: Please sign up through the Care4Bones page for the event by indicating “Are you attending: Yes”. If you are not on Care4Bones yet, please join or request the joining instructions from info@care4bones.org.

ECTS webinar on animal experimentation in skeletal research, 20th June 4pm CET

The European Calcified Tissue Society (ECTS) are organising a webinar entitled "Quo vadis animal experimentation in skeletal research?" on the 20th of June at 4pm CET, with live Q&A session with the audience.

Chair: Dr Maria-Bernadette Madel, Baylor College of Medicine, Texas, USA

Speaker: Prof Dr Jan Tuckermann, Ulm University, Ulm, Germany

Learning Objectives

• Strength and limitations of animal models, non-animal models, and in sillico approaches

• Improving reproducibility as a responsibility for science and animal welfare

• The use of experimental animals in the current research landscape and the regulations

• The holistic approach: choosing the right models to have the best science with the least harm to animals

Registration

This webinar is free and open to everyone with an interest in the field. Webinar link: https://ectsoc.org/event/bmb-jun2024/

How can we tackle collagen abnormalities in bone - a webinar by Prof Ruud A. Bank, 21st of March 4pm

Collagen abnormalities in bone pose significant challenges to skeletal health, often resulting in conditions like osteogenesis imperfecta and osteoporosis. Addressing these issues requires a multifaceted approach. Firstly, research into understanding the genetic and molecular mechanisms underlying collagen abnormalities is crucial for targeted interventions. Secondly, developing therapies that promote collagen production and stability, such as specific medications or gene therapies, could help mitigate bone fragility. Additionally, lifestyle factors such as nutrition and exercise play pivotal roles in maintaining bone health and should be emphasized in preventative measures. Moreover, advancing imaging technologies enables early detection and monitoring of collagen-related bone disorders. Collaborative efforts between clinicians, researchers, and pharmaceutical companies are essential for translating scientific discoveries into effective treatments, ultimately improving the quality of life for individuals affected by collagen abnormalities in bone.

Key takeaways: 

• Understanding the Molecular Basis:

• Holistic Approach to Treatment, that integrates pharmacological interventions, lifestyle modifications, and emerging therapies

• Ideas for collaborative Efforts for Progress

Format: Webinar of 60 minutes with presentation and a facilitated discussion. 

Audience: Everyone interested. See joining instructions. 

Joining: Please sign up through the Care4Bones page for the event by indicating “Are you attending: Yes”. If you are not on Care4Bones yet, please join or request the joining instructions from info@care4bones.org. 

About the speaker:Ruud A. Bank received his Ph.D. in 1993 at the Vrije Universiteit (Amsterdam). He started as a postdoc at TNO Quality of Life (Leiden), a non-profit contract research organization, where he investigated the role of the collagen network in connective tissue diseases (osteoarthritis, osteogenesis imperfecta, Bruck syndrome, osteoporosis, fibrosis). In 2006 he obtained a part-time position as professor at the VU Medical Center (Amsterdam). Since 2009 he is a full professor in the field of Matrix Biology and Tissue Repair at the University Medical Center Groningen.